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KMID : 0355420010250040333
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Journal of Korean Academy of Oral Health
2001 Volume.25 No. 4 p.333 ~ p.345
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Anticaries effect and cytotoxicity of extract of Soph ora flavescens Ait.
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Abstract
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The purpose of this study is to investigate anticaries activities of Sophora flavescens Ait, extracts for the prevention of dental caries caused by Streptococcus mutans. The fraction 5-4-3 of the ethyl acetate soluble extract of Sophora flavescens Ait. showed strong growth inhibition activity against Streptococcus mutans(MIC, 3.13 ug/ml ). The glucosyltransferase activity inhibited the formation of glucan by the fraction 5-4-3 and showed 77% of the antiproliferative effect at 100 ug/ml. The activity was statistically significant(p (0.05). These results suggest that the fraction 5-4-3 of the ethyl acetate soluble extract of Sophora flavescens Alt. may be a effective material on the prevention of dental caries.
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